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Clusterin is a 70-80-kDa amphiphilic molecule. It has a tendency to aggregate cells, including Sertoli cells and erythrocytes. 1999-05-25 · Clusterin is a highly conserved glycoprotein which has been proposed to protect host cells against complement-mediated cytolysis. We tested the hypothesis that clusterin is a complement regulator using erythrocytes and cells which had been stably transfected with a membrane-anchored form of clusterin as targets for complement-mediated cytolysis. Clusterin has been implicated in a number of biological processes in addition to its role in regulation of complement activation. Clusterin expression has been found to be up-regulated at sites of tissue injury, including neural tissues in Alzheimer's disease (357) and in tissues which have undergone ischemic injury (358).

Clusterin complement

complements) the ability of antibodies and phagocytic cells (a type of white blood cells) to clear microbes and damaged 22 Nov 2012 http://armandoh.org/Overview of the Complement System and the pathways involved and their relationship with each other.Image: In November 2015, Dr. Jamile Shammo of Rush University Medical Center spoke about hemolysis (destruction of red blood cells) in PNH. In this interview she A novel mutation in the complement regulator clusterin in recurrent haemolytic uraemic syndrome. / Ståhl, Anne-lie; Kristoffersson, Ann-Charlotte; Roodhooft, Status, Published - 2008. Publikationskategori, Forskning. Peer review utförd, Ja. Evenemang, 22nd International Complement Workshop - Basel, Schweiz Clusterin is a secreted protein which belongs to the Clusterin family. 4 Protein,Complement-Associated Protein SP-40,CLU,Complement Cytolysis Inhibitor Clusterin. Klusterin. Svensk definition.

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5,6 Although the association with CLU Clusterin is a multifunctional protein endowed with cell-aggregating, complement-inhibitory, and lipid-binding properties. Since several studies have demonstrated highly increased clusterin gene expression in epithelial and nervous tissues regressing as a consequence of tissue involution and apoptotic cell death, clusterin is also considered as a Clusterin is a multifunctional molecule, an inhibitor of the complement terminal pathway but also a professional molecular chaperone involved in clearance of debris . Amyloid plaques in AD are richly decorated with clusterin and a role in clearance of amyloid has been proposed [ 32, 33 ].

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Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). The present Thesis examines the expression and role of complement and the complement regulator clusterin after central or peripheral axon injury in relation to the responses of non-neuronal cells. Following peripheral sensory nerve injury, complement was expressed in the spinal cord and brain stem in association with reactive microglia, which also appeared to be a local source of complement. Clusterin antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB), Immunohistochemistry (IHC), CoImmunoprecipitation (IP),Enzyme-linked Immunosorbent Assay (ELISA) applications.

As part of the attack complex of complement, it acts as a complement inhibitor.
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Within the past 3 years,13 such genome-wide association studies (GWASs) have been published in the field of AD, highlighting more than 30 novel potential susceptibility loci with essentially no overlap in results across studies with the exception of APOE. 4 The 2 most recent GWASs implicated SNPs in clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as novel putative AD risk loci.

Complement Regulator of Complement System: Clusterin / CLU Structure Clusterin is a multifunctional plasma protein which consists of two disulfide-linked chains (α and β) that are both products of one gene. Clusterin is a 70-80-kDa amphiphilic molecule.
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Details for CPTC-CLU-1.